Ndị otu nyocha nkwonkwo sitere na Harvard Medical School (HMS) na MIT General Hospital na-ekwu na ha enwetala ndozi nke mmepụta nke laser microdisk site na iji usoro etching PEC, na-eme ka isi mmalite maka nanophotonics na biomedicine “na-ekwe nkwa.”
(Enwere ike gbanwee mmepụta nke laser microdisk site na usoro PEC etching)
N'ubi nkenanophotonicsna biomedicine, microdisklasersna nanodisk lasers aghọwo ihe na-ekwe nkwaisi mmalite ọkụna nyocha. N'ọtụtụ ngwa dị ka nkwurịta okwu photonic on-chip, on-chip bioimaging, biochemical sensing, na quantum photon information nhazi, ha kwesịrị iji nweta mmepụta laser n'ịchọpụta ogologo ogologo na ultra-wararrow band ziri ezi. Agbanyeghị, ọ ka bụ ihe ịma aka imepụta microdisk na nanodisk lasers nke ogologo ogologo ogologo a n'ọtụtụ buru ibu. Usoro nanofabrication dị ugbu a na-ewebata randomness nke dayameta diski, nke na-eme ka o sie ike ịnweta ogologo ogologo ogologo oge na nhazi na mmepụta laser. Ugbu a, otu ndị nchọpụta si Harvard Medical School na Massachusetts General Hospital's Wellman Center makaOptoelectronic ọgwụewepụtala usoro etching optochemical (PEC) nke na-enyere aka dozie ogologo ogologo laser nke microdisk n'ụzọ ziri ezi nke subnanometer. A na-ebipụta ọrụ ahụ n'akwụkwọ akụkọ Advanced Photonics.
Photochemical etching
Dị ka akụkọ si kwuo, usoro ọhụrụ nke otu ahụ na-enyere aka imepụta lasers micro-disk na nanodisk laser arrays na ogologo ogologo ikuku a kara aka. Isi ihe na-eme ka ọganihu a bụ iji PEC etching, nke na-enye ụzọ dị mma na nke nwere ike ime ka ọ dị mma iji dozie ogologo ogologo nke laser microdisc. Na nsonaazụ ndị a dị n'elu, ndị otu ahụ nwetara nke ọma indium Gallium arsenide phosphating microdisks kpuchie na silica n'usoro kọlụm indium phosphide. Ha na-elezi anya n'ogologo laser nke microdisks ndị a kpọmkwem ka ọ bara uru site n'ịrụ photochemical etching na ngwọta nke sulfuric acid.
Ha nyochakwara usoro na mgbanwe nke kpọmkwem fotochemical (PEC) etchings. N'ikpeazụ, ha bufere usoro microdisk na-emegharị ogologo ogologo n'usoro n'elu mkpụrụ osisi polydimethylsiloxane iji mepụta ụmụ irighiri ihe laser dịpụrụ adịpụ nke nwere ogologo ogologo laser dị iche iche. Microdisk pụta na-egosi bandwit ultra-wideband nke ikuku laser, yana nkelaserna kọlụm na-erughị 0.6 nm na ihe dịpụrụ adịpụ na-erughị 1.5 nm.
Mepee ụzọ maka ngwa biomedical
Nsonaazụ a na-emepe ụzọ maka ọtụtụ nanophotonics ọhụrụ na ngwa biomedical. Dịka ọmụmaatụ, laser microdisk na-eguzo naanị ya nwere ike ije ozi dị ka barcode physico-optical maka ihe atụ nke ụdị ndụ dị iche iche, na-eme ka akara nke ụdị cell dị iche iche na nlebara anya nke ụmụ irighiri ihe dị iche iche na nyocha multiplex. A na-eji akara ngosi nke cell cell ugbu a site na iji biomarkers omenala, dị otú ahụ. dị ka organic fluorophores, quantum dots, na fluorescent beads, nke nwere oke ikuku ikuku. Ya mere, ọ bụ naanị ụdị sel ole na ole ka enwere ike ịkpọ n'otu oge. N'ụzọ dị iche, ultra-narrow band light emission nke microdisk laser ga-enwe ike ịchọpụta ụdị sel ndị ọzọ n'otu oge.
Ndị otu a nwalere wee gosipụta nke ọma n'ụzọ ziri ezi microdisk laser particles dị ka biomarkers, na-eji ha na-akara omenala ara epithelial cell MCF10A. Site na ikuku ultra-wideband ha, lasers ndị a nwere ike gbanwee biosensing, na-eji usoro biomedical na ngwa anya dị ka onyonyo cytodynamic, cytometry eruba, na nyocha multi-omics. Teknụzụ dabere na PEC etching bụ nnukwu ọganihu na laser microdisk. The scalability nke usoro, yana subnanometer nkenke ziri ezi, na-emepe ọhụrụ ohere maka ọtụtụ ngwa nke lasers na nanophotonics na biomedical ngwaọrụ, yana barcodes maka kpọmkwem ọnụ ọgụgụ cell na nyocha ụmụ irighiri.
Oge nzipu: Jan-29-2024